| 汤姆·汉克斯 | Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry | — |
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| 哈莉·贝瑞 | Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym | — |
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| 吉姆·布劳德本特 | Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2 | — |
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| 雨果·维文 | Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie | — |
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| 吉姆·斯特吉斯 | Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother-in-Law | — |
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| 裴斗娜 | Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute | — |
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| 本·卫肖 | Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman | — |
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| 詹姆斯·达西 | Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist | — |
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| 周迅 | Talbot / Hotel Manager / Yoona-939 / Rose | — |
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| 基思·大卫 | Kupaka / Joe Napier / An-kor Apis / Prescient | — |
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| 苏珊·萨兰登 | Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess | — |
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| 休·格兰特 | Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks / Denholme Cavendish / Seer Rhee / Kona Chief | — |
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